Team 5 : Mohamed Benahmed
Physiopathologic aspects of germ cell proliferation : genomic and non genomic effects
 
Previous activities

Identification of the genes involved in the control of germ cell  proliferation and characterization of the molecular mechanisms leading to abnormal expresion should allow a better understanding of germinal insufficiency, testicular or prostatic carcinogenesis and their links with environment.
Group 1 (G.Pointis) studies the connexins (Cx) involved in the control of germ cell proliferation, interactions between these different connexins especially Cx 43 and 33, and their relation with other partners of the junctional plate (ZO-1, cSrc, N-cadherin, REG) and is looking for modification of these relations in germ cell proliferation disturbances with a special interest in traffic troubles described for Cx in most pathological circonstances (cancer, exposition to tumoral promoters). 
Group 2 (P.Fénichel) studies the role of estrogen receptors, androgen receptors and apoptotic actors using an experimental model of wild type and genetically modified mice exposed to endocrine disruptors (xenoestrogens and antiandrogens) in order to identify the mechanisms of exaggerated apoptosis associated to hypofertility and exaggerated proliferation associate with malignant cell proliferation.  This study has a particular concern in hormone dependent epigenetic modifications possibly induced in utero and able to induce transcriptional alterations in adult.
All these aspects concern works on cell lines, transgenic models, human collections (testicular biopsies and testicular tumors) obtained through clinical networks. They take also advantage of the insertion in the axis 1 of C3M called cancer, apoptosis, proliferation, and of the support of grants (Inca, ANR, Europe) of industrial partners (Pfizer, Bayer/CropScience and Schering) and will allow medical application and valorisation (prevention, biotest of toxicity, early diagnosis markers, and therapeutical targets).

Major Publications

2015

Chevalier N, Brucker-Davis F, Lahlou N, Coquillard P, Pugeat M, Pacini P, Panaïa-Ferrari P, Wagner-Mahler K, Fénichel P. A negative correlation between insulin-like peptide 3 and bisphenol A in human cord blood suggests an effect of endocrine disruptors on testicular descent during fetal development. Hum Reprod. 2015 Feb;30(2):447-53.

Chevalier N, Paul-Bellon R, Fénichel P. A commentary on "Involvement of activating ERK1/2 trough G protein coupled receptor 30 and estrogen receptor α/β in low doses of bisphenol A promoting growth of Sertoli TM4 cells". Toxicol Lett. 2015 Mar 7

2014

Simeoni U, Yzydorczyk C, Siddeek B, Benahmed M. Epigenetics and neonatal nutrition. Early Hum Dev. 2014 Sep;90 Suppl 2:S23-4.

Siddeek B, Inoubli L, Lakhdari N, Rachel PB, Fussell KC, Schneider S, Mauduit C, Benahmed M. MicroRNAs as potential biomarkers in diseases and toxicology. Mutat Res. 2014 Jan 30. pii: S1383-5718(14)

Chevalier N, Paul-Bellon R, Camparo P, Michiels JF, Chevallier D, Fénichel P. Genetic variants of GPER/GPR30, a novel estrogen-related G protein receptor, are associated with human seminoma. Int J Mol Sci. 2014 Jan 21;15(1):1574-89.

2013

Vialard F, El Sirkasi M, Tronchon V, Boudjenah R, Molina-Gomes D, Bergere M, Mauduit C, Wainer R, Selva J, Benahmed M. Tumor necrosis factor-308 polymorphism increases the embryo implantation rate in women undergoing in vitro fertilization. Hum Reprod. 2013 Aug 1.

Koraïchi F, Inoubli L, Lakhdari N, Meunier L, Vega A, Mauduit C, Benahmed M, Prouillac C, Lecoeur S. Neonatal exposure to zearalenone induces long term modulation of ABC transporter expression in testis. Toxicology. 2013 Aug 9;310:29-38.

2012

Chevallier D, Carette D, Segretain D, Gilleron J, Pointis G. Connexin 43 a check-point component of cell proliferation implicated in a wide range of human testis diseases. Cell Mol Life Sci. 2012 Aug 24


Moussata D, Amara S, Siddeek B, Decaussin M, Hehlgans S, Paul-Bellon R, Mornex F, Gerard JP, Romestaing P, Rödel F, Flourie B, Benahmed M, Mauduit C. XIAP as a  radioresistance factor and prognostic marker for radiotherapy in human rectal adenocarcinoma. Am J Pathol. 2012 Oct;181(4):1271-8.


Gilleron J, Carette D, Chevallier D, Segretain D, Pointis G. Molecular connexin partner remodeling orchestrates connexin traffic: from physiology to pathophysiology. Crit Rev Biochem Mol Biol. 2012 Sep;47(5):407-23.


Chevalier N, Vega A, Bouskine A, Siddeek B, Michiels JF, Chevallier D, Fénichel P. GPR30, the non-classical membrane G protein related estrogen receptor, is overexpressed in human seminoma and promotes seminoma cell proliferation. PLoS One. 2012;7(4):e34672.


Meunier L, Siddeek B, Vega A, Lakhdari N, Inoubli L, Bellon RP, Lemaire G, Mauduit C, Benahmed M. Perinatal programming of adult rat germ cell death after exposure to xenoestrogens: role of microRNA miR-29 family in the down-regulation  of DNA methyltransferases and Mcl-1. Endocrinology. 2012 Apr;153(4):1936-47.

2011

Chevalier N, Bouskine A, Fenichel P. Role of GPER/GPR30 in tumoral testicular  germ cells proliferation. Cancer Biol Ther. 2011 Jul 1;12(1):2-3. doi: 10.4161/cbt.12.1.15726. Epub 2011 Jul 1. PubMed PMID: 21508670.

Vindrieux D, Reveiller M, Chantepie J, Yakoub S, Deschildre C, Ruffion A, Devonec M, Benahmed M, Grataroli R. Down-regulation of DcR2 sensitizes androgen-dependent prostate cancer LNCaP cells to TRAIL-induced apoptosis. Cancer Cell Int. 2011 Dec 2;11(1):42. [Epub ahead of print] PubMed PMID: 22136382.

Gilleron J, Malassiné A, Carette D, Segretain D, Pointis G. Chemical connexin  impairment in the developing gonad associated with offspring infertility. Curr Med Chem. 2011 Nov 1;18(33):5145-58. PubMed PMID: 22050760.

Mauro V, Volle DH, Chevallier D, Haudebourg J, Sénégas-Balas F, Pointis G. Regenerating I messenger RNA and protein expression in the failing human testis:  a potential molecular prognostic marker of seminoma. Hum Pathol. 2011 Dec;42(12):1841-8. Epub 2011 Jun 17. PubMed PMID: 21683984.

Gilleron J, Carette D, Fiorini C, Dompierre J, Macia E, Denizot JP, Segretain  D, Pointis G. The large GTPase dynamin2: a new player in connexin 43 gap junction endocytosis, recycling and degradation. Int J Biochem Cell Biol. 2011 Aug;43(8):1208-17. Epub 2011 Apr 27. PubMed PMID: 21554976.

Chevalier N, Bouskine A, Fenichel P. Bisphenol A promotes testicular seminoma  cell proliferation through GPER/GPR30. Int J Cancer. 2012 Jan 1;130(1):241-2. doi: 10.1002/ijc.25972. Epub 2011 Apr 27. PubMed PMID: 21312194.

Carette D, Weider K, Gilleron J, Giese S, Dompierre J, Bergmann M, Brehm R, Denizot JP, Segretain D, Pointis G. Major involvement of connexin 43 in seminiferous epithelial junction dynamics and male fertility. Dev Biol. 2010 Oct  1;346(1):54-67. Epub 2010 Jul 22. PubMed PMID: 20655897.

Belli P, Bellaton C, Durand J, Balleydier S, Milhau N, Mure M, Mornex JF, Benahmed M, Le Jan C. Fetal and neonatal exposure to the mycotoxin zearalenone induces phenotypic alterations in adult rat mammary gland. Food Chem Toxicol. 2010 Oct;48(10):2818-26. Epub 2010 Jul 14. PubMed PMID: 20637251.

Pointis G, Gilleron J, Carette D, Segretain D. Physiological and physiopathological aspects of connexins and communicating gap junctions in spermatogenesis. Philos Trans R Soc Lond B Biol Sci. 2010 May 27;365(1546):1607-20. Review. PubMed PMID: 20403873; PubMed Central PMCID: PMC2871914.

Chevalier N, Barlier A, Roche C, Mograbi B, Camparo P, Devouassoux-Shisheboran M, Michiels JF, Nebout M, Chevallier D, Benahmed M, Enjalbert A, Fénichel P. RET gene mutations are not involved in the origin of human testicular seminoma. Int J Androl. 2010 Dec;33(6):848-52. doi: 10.1111/j.1365-2605.2009.01043.x. PubMed PMID: 20201982.

Segretain D, Gilleron J, Carette D, Denizot JP, Pointis G. Differential time  course of FSH/FSH receptor complex endocytosis within sertoli and germ cells during rat testis development. Dev Dyn. 2010 Apr;239(4):1113-23. PubMed PMID: 20201104.

Carette D, Gilleron J, Segretain D, Pointis G. Heteromeric connexin 43/connexin 33 complex endocytosis: a connexin phosphorylation independent mechanism. Biochimie. 2010 May;92(5):555-9. Epub 2010 Feb 10. PubMed PMID: 20152878.

2010

Pointis G, Gilleron J, Carette D, Segretain D. Physiological and physiopathological aspects of connexins and communicating gap junctions in spermatogenesis. Philos Trans R Soc Lond B Biol Sci. 2010 May 27;365(1546):1607-20

Bouskine, A., A. Vega, M. Nebout, M. Benahmed, and P. Fenichel. Expression of embryonic stem cell markers in cultured JKT-1, a cell line derived from a human seminoma. Int J Androl. 2010; 33:54-63

Brucker-Davis F, Wagner-Mahler K, Bornebusch L, Delattre I, Ferrari P, Gal J, Boda-Buccino M, Pacini P, Tommasi C, Azuar P, Bongain A, Fénichel P. Exposure to selected endocrine disruptors and neonatal outcome of 86 healthy boys from Nice area (France).Chemosphere. 2010 Jul 19.

Carette C., Weider K., Gilleron J., Giese S., Dompierre J., Bergmann M., Brehm R., Denizot J.P., Segretain D., PointisG. (2010) Major involvement of connexin 43 in seminiferous epithelial junction dynamics and male fertility. Dev. Biol. Jul 22. in press

Masini M.A., Prato P., Scarabelli L., Lanza C., Palmero S., Pointis G., Ricci F., Strollo F. (2010) In vitro effects of simulated microgravity on Sertoli cell function. Advances in Space Research in press

Mauro  V., Volle  D.H., Chevallier  D., Haudebourg  J., Sénégas-Balas  F., Pointis G. (2010) Reg I mRNA and protein expression in the failing human testis: a potential molecular prognostic marker of seminoma. Hum. Pathol. in press

Perrard M.H., Grenet C., Prisant N., Geoffroy-Siraudin C., Segretain D., Guichaoua M.R., Pointis G., Durand P. (2010) De l’étude des mécanismes de régulation de la spermatogenèse à la reprotoxicologie par approche ex vivo : pour une meilleure application de REACH. Médecine Science, 26, 305-310

Segretain D., Gilleron J., Carette D., Denizot J.P., Pointis G. (2010) Differential time course of FSH/FSH receptor complex endocytosis within Sertoli and germ cells during rat testis development. Dev. Dyn. 239, 1113-1123.

Belli P, Bellaton C, Durand J, Balleydier S, Milhau N, Mure M, Mornex JF, Benahmed M, Le Jan C.
Fetal and neonatal exposure to the mycotoxin zearalenone induces phenotypic alterations in adult rat mammary gland.Food Chem Toxicol. 2010 Oct;48(10):2818-26. 

Rezg R, Mornagui B, Benahmed M, Chouchane SG, Belhajhmida N, Abdeladhim M, Kamoun A, El-fazaa S, Gharbi N. Malathion exposure modulates hypothalamic gene expression and induces dyslipedemia in Wistar rats. Food Chem Toxicol. 2010 Jun;48(6):1473

Chevalier N, Barlier A, Roche C, Mograbi B, Camparo P, Devouassoux-Shisheboran M, Michiels JF, Nebout M, Chevallier D, Benahmed M, Enjalbert A, Fénichel P. RET gene mutations are not involved in the origin of human testicular seminoma. Int J Androl. 2010 Feb 23.

Carette D, Gilleron J, Segretain D, Pointis G. Heteromeric connexin 43/connexin 33 complex endocytosis: a connexin phosphorylation independent mechanism. Biochimie. 2010 May;92(5):555-9.

2009

Gilleron J, Carette D, Carpentier F, Segretain D, Pointis G. Three-dimensional analysis of connexin 43 gap junction in the ex vivo rat seminiferous tubules: short-term effects of hormonal effectors. Microsc Res Tech. 2009 Nov;72(11):845-55

Hammami I, Amara S, Benahmed M, El May MV, Mauduit C. Chronic crude garliic-feeding modified adult male rat testicular markers :mechanisms of action. Reprod Biol E,docrinol 2009, 24:7-65.

Volle DH, Decourteix M, Garo E, McNeilly , Fénichel P., Auwerx J, McNeilly AS, Schoonjans K, Benahmed M; The Orphan nuclear receptor small heterodimer partner mediates male infertility induced by diethylstilbestrol in mice. J Clin Invest 2009, 119, 3752-3764

Carette D, Gilleron J, Decrouy X, Fiorini C, Diry M, Segretain D, Pointis G. Connexin 33 impairs gap junction functionality by accelerating connexin 43 gap junction plaque endocytosis. Traffic. 2009 Sep;10(9):1272-85.

Pointis G, Fiorini C, Gilleron J, Carette D and Segretain D. Connexins in the Male Reproductive System.
Chapter 25,495-510, Connexins a guide Edited by Andrew Harris and Darren Locke Humana Press.

Bouskine A, Vega A, Nebout M, Benahmed M, Fénichel P. Expression of embryonic stem cell markers in cultured JKT-1, a cell line derived from a human seminoma. Int J Androl. 2009 Feb 10.

Bouskine A, Nebout M, Brücker-Davis F, Benahmed M, Fenichel P. Low doses of bisphenol A promote human seminoma cell proliferation by activating PKA and PKG via a membrane G-protein-coupled estrogen receptor. Environ Health Perspect. 2009 Jul;117(7):1053-8.

Gilleron J, Carette D, Fiorini C, Benkdane M, Segretain D, Pointis G. Connexin 43 gap junction plaque endocytosis implies molecular remodelling of ZO-1 and c-Src partners. Commun Integr Biol. 2009;2(2):104-6.

Pointis, Gilleron J, Carette, Segretain D. Physiological and physiopathological aspects of connexins and communicating gap junctions in spermatogenesis. Philosophical Transactions B 2009, invited paper.

2008

Angulo C, Castro MA, Rivas CI, Segretain D, Maldonado R, Yañez AJ, Slebe JC, Vera JC, Concha II. Molecular identification and functional characterization of the vitamin C transporters expressed by Sertoli cells. J Cell Physiol. 2008, 217: 708-716.

Baker SM, Kim N, Gumpert AM, Segretain D, Falk MM. Acute internalization of gap junctions in vascular endothelial cells in response to inflammatory mediator-induced G-protein coupled receptor activation. FEBS Lett., 2008, 582: 4039-4046.

Benbrahim-Tallaa L, Siddeek B, Bozec A, Tronchon V, Florin A, Friry C, Tabone E, Mauduit C, Benahmed M. Alterations of Sertoli cell activity in the long-term testicular germ cell death process induced by fetal androgen disruption. J Endocrinol., 2008, 196(1): 21-31.

Bouskine A, Nebout M, Mograbi B, Brücker-Davis F, Roger C, Fenichel P. Estrogens promote human testicular germ cell cancer through a membrane-mediated activation of extracellular regulated kinase and protein kinase A. Endocrinology, 2008; 149(2): 565-573.

Bozec A, Amara S, Guarmit B, Selva J, Albert M, Rollet J, El Sirkasi M, Vialard F, Bailly M, Benahmed M, Mauduit C. Status of the executioner step of apoptosis in human with normal spermatogenesis and azoospermia. Fertil Steri,. 2008, ;90(5): 1723-1731.

Brucker-Davis F, Ducot B, Wagner-Mahler K, Tommasi C, Ferrari P, Pacini P, Boda-Buccino M, Bongain A, Azuar P, Fénichel P. Environmental pollutants in maternal milk and cryptorchidism. Gynecol Obstet Fertil. French, 2008, 36(9): 840-847.

Brucker-Davis F, Wagner-Mahler K, Delattre I, Ducot B, Ferrari P, Bongain A, Kurzenne JY, Mas J.C, Fénichel P; Cryptorchidism Study Group from Nice Area. Cryptorchidism at birth in Nice area (France) is associated with higher prenatal exposure to PCBs and DDE, as assessed by colostrum concentrations. Hum Reprod, 2008, 23(8):1708-1718.

Decourteix M, Alves G, Bonhomme M, Peuch M, Ben Baaziz K, Brunel N, Guilliot A, Rageau R, Améglio T, Pétel G, Sakr S. Sucrose (JrSUT1) and hexose (JrHT1 and JrHT2) transporters in walnut xylem parenchyma cells: their potential role in early events of growth resumption. Tree Physiol. 2008, 28(2): 215-224.

Duggavathi r, Volle D.H, Mataki C, Antal M.C., Messaddeq N, Auwerx J, Murphy B.D., Schoonjans K. Liver receptor homolog 1 is essential for ovulation. Genes Dev.2008, 22(4): 1871-1876

Fénichel P, Brucker-Davis F. Environmental endocrine disruptors and breast cancer : new risk factors ? Gynecol Obstet Fertil,. Review. French. 2008, 10: 969-977.

Fenichel P, Bstandig B, Roger C, Chevallier D, Michels J.F., Sadoul J.L., Hieronimus S, Brucker-Davis F. Unilateral testicular tumour associated to congenital adrenal hyperplasia: Failure of specific tumoral molecular markers to discriminate between adrenal rest and leydigioma. Ann Endocrinol (Paris), 2008, 69(5):453-458.

Fénichel P, Letur H. Procreation in Turner's syndrome: which recommendations before, during and after pregnancy? Gynecol Obstet Fertil. Review. French., 2008, 36 (9): 891-897.

Fiorini C, Gilleron J, Carette D, Valette A, Tilloy A, Chevalier S, Segretain D, Pointis G. Accelerated clathrin-dependent internalization of junctional proteins within endocytic vacuoles as an early event to the carcinogen DDT. BBA, 2008, 1778: 56-67.

Gilleron J, Fiorini C, Carette D, Avondet C, Falk MM, Segretain D, Pointis G. Molecular reorganization of the connexin 43, Zonula occludens-1 and c-Src complexes during gap junction plaque endocytosis in response to a non genomic carcinogen. J Cell Sc, 2008, 121: 4069-4078.

Hammami I, Nahdi A, Mauduit C, Benahmed M, Amri M, Ben Amar A, Zekri S, El May A, El May MV. The inhibitory effects on adult male reproductive functions of crude garlic (Allium sativum) feeding. Asian J Androl, 2008, 10(4): 593-601.

Joly-Pharaboz MO, Kalach JJ, Pharaboz J, Chantepie J, Nicolas B, Baille ML, Ruffion A, Benahmed M, André J. Androgen inhibits the growth of carcinoma cell lines established from prostate cancer xenografts that escape androgen treatment. J Steroid Biochem Mol Biol, 2008, 111(1-2): 50-59.

Léotoing L, Meunier L, Manin M, Mauduit C, Decaussin M, Verrijdt G, Claessens F, Benahmed M, Veyssière G, Morel L, Beaudoin C. Influence of nucleophosmin/B23 on DNA binding and transcriptional activity of the androgen receptor in prostate cancer cell. Oncogene, 2008, 27(20): 2858-2867.

Mauro V, Carette D, Chevallier D , Michiels JF, Segretain D, Pointis G, Senegas-Balas F. Demonstration of REG 1 protein in healthy and seminoma human testis. Histol. Histopathol, 2008, 23: 1195-1203.

Mauro V, Chevallier D, Gilleron J, Defamie N, Carette D, Gasc J.M, Senegas-Balas F, Segretain D, Pointis G. Aberrant cytoplasmic accumulation of connexin 43 in human testicular seminoma. The Open Biomarkers Journal, 2008, 1: 20-27.

Nieminen K, Immanen J, Laxell M, Kauppinen L, Tarkowski P, Dolezal K, Tähtiharju S, Elo A, Decourteix M, Ljung K, Bhalerao R, Keinonen K, Albert VA, Helariutta Y.. Cytokinin signaling regulates cambial development in poplar. Proc Natl Acad Sci U S A. 2008, 105(50): 20032-20037

Niger C, Geneau G, Fiorini C, Pointis G, Mesnil M, Cronier L. Endothelin-1 inhibits human osteoblastic cell differentiation: influence of connexin 43 expression level. J. Cell. Biochem. 2008 103: 110-122.

Pointis G, Fiorini C, Gilleron J, Carette D, Segretain D. Role of connexins in the male reproductive system. Ed A Harris and D. Locke. Humana Press, Totowa NJ, USA, 2008, 495-510.

Segretain D, Gilleron J, Carette D, Denizot J.P, Pointis G. Kinetic of FSH endocytosis in neonatal and mature rat Sertoli and germ cells. Micros Res Tech in press, invited paper.

Starita-Geribaldi M, Samson M, Guigonis J.M, Pointis G, Fenichel P. Modified expression of cytoplasmic isocitrate dehydrogenase electrophoretic isoforms in seminal plasma of men with sertoli-cell-only syndrome and seminoma. Mol Carcinog, 2008, 47(6):410-414.

Tronchon V, Vialard F, El Sirkasi M, Dechaud H, Rollet J, Albert M, Bailly M, Roy P, Mauduit C, Fenichel P, Selva J, Benahmed M. Tumor necrosis factor-alpha -308 polymorphism in infertile men with altered sperm production or motility. Hum Reprod., 2008, 12: 2858-2866.


Corcelle E, Djerbi N, Mari M, Nebout M, Fiorini C, Fénichel P, Hofman P, Poujeol P, Mograbi B. Control of the Autophagy Maturation Step by the MAPK ERK and p38 : Lessons from Environmental Carcinogens. Autophagy, 2007 Jan 21.3 (1)

Piehl M, Lehmann C, Gumpert A, Denizot J-P, Segrétain D, and Falk M.M. Internalization of large double-membrane intercellular vesicles by a clathrin-dependent endocytic process. Mol Biol Cell 2006 Nov 15 [epub ahead of print].

Gilleron J, Nebout N, Scarabelli L, Sénégas-Balas F, Palmero S, Segretain D and Pointis G. A potential novel mechanism involving connexin 43 gap junction for control of sertoli cell proliferation by thyroid hormones. J. Cell Physiol. 2006, 209 :153-161.

El Chami N, Ikhlef F, Kaszas K, Yakoub S, Tabone E, Siddeek B, Cunha S, Beaudoin C, Morel L, Benahmed M, Regnier DC.Androgen-dependent apoptosis in male germ cells is regulated through the proto-oncoprotein Cbl. J. Cell Biol. 2005 171:651-661.

Pointis G, Segretain D. Role of connexin-based gap junction channels in testis. Trends Endocrinol. Metab. 2005, 16: 300-306.

Roger C, Lambard S, Bouskine A, Mograbi B, Chevallier D, Nebout M, Pointis G, Carreau S, Fénichel P. Estrogen-induced growth inhibition of human seminoma cells expressing estrogen receptor ß and aromatase. J. Mol. Endocrinol. 2005, 35:191-199.

El Chami N, Ikhlef F, Kaszas K, Yakoub S, Tabone E, Siddeek B, Cunha S, Beaudoin C, Morel L, Benahmed* M, Regnier *DC Androgen-dependent apoptosis in male germ cells is regulated trough the proto-oncoprotein Cbl. J Cell Biol 2005, 171, 651-661.

Fiorini C, Mograbi B, Cronier L, Bourget I, Decrouy X, Ferrrua B, Malassiné A, Samson M, Fénichel P, Segretain D, Pointis G. The dominant negative effect of connexin 33 on gap junctional intercellular communication is mediated through a selective sequestration of connexin 43. J Cell Sci. 2004, 117:4665-4672.

Roger C, Mograbi B, Chevallier D, Michiels JF, Tanaka H, Segretain D, Pointis G , Fénichel P. Disrupted traffic of Connexin 43 in human testicular seminoma cells: overexpression of Cx43 induces membrane location and cell proliferation decrease. J. Pathol. 2004, 202 :241-246.

 
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Team leader

 
Researcher
M. BENAHMED
Clinical researcher
P. FENICHEL
F. BRUCKER-DAVIES
C. MAUDUIT
N. CHEVALIER
Postdoc
Student
L. INOUBLI
K. GHARIB
W. BEN-SALEM
Research assistant
R. BELLON
C. BARBE
 
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