Cholera toxin notches epithelial junctions

Lemichez E, Stefani C

Cell Host Microbe 2013 Sep;14(3):227-9

Abstract

PMID: 24034608

Cholera toxin (CT) is the factor responsible for watery diarrhea associated with Vibrio cholerae infection. In this issue, Guichard et al. (2013) report that CT compromises intestinal epithelium barrier function via cyclic AMP (cAMP)-induced disruption of Rab11- and exocyst-dependent delivery of endocytic recycling cargo to cell-cell junctions.