Project: Amyotrophic lateral sclerosis is a devastating disease affecting upper and lower motor neurons leading to progressive failure of the neuromuscular system and death from respiratory failure. Among all factors involved in ALS pathogenesis, mitochondrial dysfunction has always been recognized as a candidate major player. However, whether mitochondria have a causative role in ALS has been always debated. Our results open a new field to explore the pathogenesis of motor neuron disease by showing that mitochondrial dysfunction may be at the origin of some of these phenotypes.
Our goals are
(i) to better characterize the role of the CHCHD10 protein on cell death and to compare the effects of different CHCHD10 mutations leading to different clinical phenotypes,
(ii) to understand how CHCHD10 mutations lead to motor neuron cell death by generating specific human cellular (IPS) and characterizing in vivo models
The candidate should hold a PhD in physiology, pharmacology or related disciplines and have previous expertise in induced pluripotent stem cells (IPS) generation/characterization (required) and She/he should be skilled in in vivo animal experimentation techniques (required) as well as in cellular and molecular biology techniques. Practice or knowledge of primary motor neuron culture and analysis would be appreciated.
Candidates should send a curriculum vitae with publication list, a short summary of research achievements, and the names and email addresses of at least two references to firstname.lastname@example.org