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Accueil du site > Équipes > Molécules Bioactives > Thème Ligands d’Acides Nucléiques (Targeting of Nucleic Acids research group)

Thème Ligands d’Acides Nucléiques (Targeting of Nucleic Acids research group)

Introduction

RNA represents a major biological target for future drug development, because it is involved in a wide number of biological processes, such as transcription, translation or catalysis and more importantly it is essential for the regulation of gene expression. Most biologically relevant RNAs bear a three-dimensional structure containing single-stranded regions (loops and bulges) associated to double-stranded regions that offers the possibility for selective/specific binding interactions with proteins and small-molecule ligands. The main goal of our research activities is to design and synthesize new RNA ligands bearing both strong affinity and high selectivity for a biologically relevant RNA target and to study the interactions involved in the formation of the ligand-RNA complex using biochemical and biophysical techniques.