2015
Regazzetti C, Dumas K, Lacas-Gervais S, Pastor F, Peraldi P, Bonnafous S,
Dugail I, Le Lay S, Valet P, Le Marchand-Brustel Y, Tran A, Gual P, Tanti JF,
Cormont M, Giorgetti-Peraldi S. Hypoxia inhibits Cavin-1 and Cavin-2 expression
and down-regulates caveolae in adipocytes. Endocrinology. 2015
Mar;156(3):789-801
Dirat B, Ader I, Golzio M, Massa F, Mettouchi A, Laurent K, Larbret F, Malavaud B, Cormont M, Lemichez E, Cuvillier O, Tanti JF, Bost F. Inhibition of the GTPase Rac1 Mediates the Antimigratory Effects of Metformin in Prostate Cancer Cells. Mol Cancer Ther. 2015 Feb;14(2):586-96.
2014
Ceppo F, Jager J, Berthou F, Giorgetti-Peraldi S, Cormont M, Bost F, Tanti JF.
[Implication of MAP kinases in obesity-induced inflammation and insulin
resistance]. Biol Aujourdhui. 2014;208(2):97-107.2014 Sep 8. French. .
Tannour-Louet M, York B, Tang K, Stashi E, Bouguerra H, Zhou S, Yu H, Wong LJ,
Stevens RD, Xu J, Newgard CB, O'Malley BW, Louet JF. Hepatic SRC-1 activity
orchestrates transcriptional circuitries of amino acid pathways with potential
relevance for human metabolic pathogenesis. Mol Endocrinol. 2014
Oct;28(10):1707-18.
Ceppo F, Berthou F, Jager J, Dumas K, Cormont M, Tanti JF. Implication of the
Tpl2 kinase in inflammatory changes and insulin resistance induced by the
interaction between adipocytes and macrophages. Endocrinology. 2014
Mar;155(3):951-64.
2013
Perrin L, Lacas-Gervais S, Gilleron J, Ceppo F, Prodon F, Benmerah A, Tanti
JF, Cormont M. Rab4b controls an early endosome sorting event by interacting with
the γ-subunit of the clathrin adaptor complex 1. J Cell Sci. 2013 Nov 1;126
Tanti JF, Ceppo F, Jager J, Berthou F. Implication of inflammatory signaling
pathways in obesity-induced insulin resistance. Front Endocrinol (Lausanne). 2013
Jan 8;3:181.
Ben-Sahra I, Dirat B, Laurent K, Puissant A, Auberger P, Budanov A, Tanti JF,
Bost F. Sestrin2 integrates Akt and mTOR signaling to protect cells against
energetic stress-induced death. Cell Death Differ. 2013 Apr;20(4):611-9.
2012
Regazzetti C, Dumas K, Le Marchand-Brustel Y, Peraldi P, Tanti JF, Giorgetti-Peraldi S. Regulated in Development and DNA Damage Responses -1 (REDD1) Protein Contributes to Insulin Signaling Pathway in Adipocytes. PLoS One. 2012;7(12):e52154.
Ben-Sahra I, Dirat B, Laurent K, Puissant A, Auberger P, Budanov A, Tanti JF, Bost F. Sestrin2 integrates Akt and mTOR signaling to protect cells against energetic stress-induced death. Cell Death Differ. 2012 Dec 14.
Bost F, Ben-Sahra I, Tanti JF. Prevention of mutagenesis: new potential mechanisms of metformin action in neoplastic cells. Cancer Prev Res (Phila). 2012 Apr;5(4):503-6.
Bost F, Sahra IB, Le Marchand-Brustel Y, Tanti JF. Metformin and cancer therapy. Curr Opin Oncol. 2012 Jan;24(1):103-8.
2011
Ben Sahra I, Regazzetti C, Robert G, Laurent K, Le Marchand-Brustel Y, Auberger P, Tanti JF, Giorgetti-Peraldi S, Bost F. Metformin, independent of AMPK, induces mTOR inhibition and cell-cycle arrest through REDD1. Cancer Res. 2011 Jul 1;71(13):4366-72. Epub 2011 May 3..
Plaisant M, Giorgetti-Peraldi S, Gabrielson M, Loubat A, Dani C, Peraldi P. Inhibition of hedgehog signaling decreases proliferation and clonogenicity of human mesenchymal stem cells. PLoS One. 2011 Feb 3;6(2).
2010
Jager J, Corcelle V, Grémeaux T, Laurent K, Waget A, Pagès G, Binétruy B, Le Marchand-Brustel Y, Burcelin R, Bost F, Tanti JF : Deficiency in the extracellular signal-regulated kinase 1 (ERK1) protects leptin-deficient mice from insulin resistance without affecting obesity. Diabetologia. 2010 Oct 15
Sahra IB, Tanti JF, Bost F : The combination of metformin and 2-deoxyglucose inhibits autophagy and induces AMPK dependent apoptosis in prostate cancer cells. Autophagy. 2010 Jul 21;6(5)
Ben Sahra I, Le Marchand-Brustel Y, Tanti JF, Bost F : Metformin in cancer therapy: a new perspective for an old antidiabetic drug? Mol Cancer Ther. 2010 May;9(5):1092-9. Review
Dray C, Debard C, Jager J, Disse E, Daviaud D, Martin P, Attané C, Wanecq E, Guigné C, Bost F, Tanti JF, Laville M, Vidal H, Valet P, Castan-Laurell I : Apelin and APJ regulation in adipose tissue and skeletal muscle of type 2 diabetic mice and humans. Am J Physiol Endocrinol Metab. 2010 Jun;298(6):E1161-9
Ben Sahra I, Laurent K, Giuliano S, Larbret F, Ponzio G, Gounon P, Le Marchand-Brustel Y, Giorgetti-Peraldi S, Cormont M, Bertolotto C, Deckert M, Auberger P, Tanti JF, Bost F. Targeting cancer cell metabolism: the combination of metformin and 2-deoxyglucose induces p53-dependent apoptosis in prostate cancer cells. Cancer Res. 2010 Mar 15;70(6):2465-75.
Regazzetti C, Bost F, Le Marchand-Brustel Y, Tanti JF, Giorgetti-Peraldi S. Insulin induces REDD1 expression through hypoxia-inducible factor 1 activation in adipocytes. J Biol Chem. 2010 Feb 19;285(8):5157-64.
Jager J, Grémeaux T, Gonzalez T, Bonnafous
S, Debard C, Laville M, Vidal H, Tran A, Gual P, Le Marchand-Brustel
Y, Cormont M, Tanti JF. The Tpl2 kinase is up-regulated
in adipose tissue in obesity and may mediate IL-1{beta} and TNF-{alpha}
effects on ERK activation and lipolysis.
Diabetes. 2010 Jan;59(1):61-70 Lien
publication
2009
Oldani A, Cormont M, Hofman V, Chiozzi
V, Oregioni O, Canonici A, Sciullo A, Sommi P, Fabbri A, Ricci V,
Boquet P.Helicobacter pylori counteracts
the apoptotic action of its VacA toxin
by injecting the CagA protein into gastric epithelial cells.
PLoS Pathog. 2009 Oct;5(10):e1000603.
Lien
publication
Tanti JF and Jager J. Cellular
mechanisms of insulin resistance: role
of stress-regulated serine kinases and
insulin receptor substrates (IRS) serine
phosphorylation. Curr Opin Pharmacol.
2009 Aug 13.Lien publication
Vincent Kaddai, Teresa Gonzalez,
Frédérique Keslair, Thierry Grémeaux, Stéphanie Bonnafous, Jean Gugenheim,
Albert Tran, Philippe Gual, Yannick Le Marchand-Brustel and Mireille
Cormont.
Rab4b is a small GTPase involved in the
control of the glucose transporter GLUT4 localization in adipocyte
PLoS ONE, Avril 2009 (http://dx.plos.org/10.1371/journal.pone.0005257)
Kaddai
V, Jager J, Gonzalez T, Najem-Lendom R, Bonnafous S, Tran A, Le Marchand-Brustel
Y, Gual P, Tanti JF, Cormont M.
Involvement of TNF-alpha in abnormal adipocyte and muscle sortilin expression
in obese mice and humans. Diabetologia. 2009 May;52(5):932-40. Epub 2009 Feb
14.
Poggi
M, Jager J, Paulmyer-Lacroix O, Peiretti F, Gremeaux T, Verdier M,
Grino M, Stepanian A, Msika S, Burcelin R, de Prost D, Tanti JF,
Alessi MC.
The inflammatory receptor CD40 is expressed on human adipocytes: contribution
to crosstalk between lymphocytes and adipocytes. Diabetologia. 2009 Jun;52(6):1152-63.
Epub 2009 Jan 31.
Regazzetti C, Peraldi P, Grémeaux
T, Najem-Lendom R, Ben-Sahra I, Cormont M, Bost F, Le Marchand-Brustel
Y, Tanti JF, Giorgetti-Peraldi S.
Hypoxia decreases insulin signaling pathways in adipocytes.
Diabetes. 2009 Jan;58(1):95-103. Epub 2008 Nov 4.
2008
Kaddai V, Gonzalez
T, Bolla M, Le Marchand-Brustel Y, Cormont M.
The nitric oxide-donating derivative
of acetylsalicylic acid, NCX 4016, stimulates glucose transport and
glucose transporters translocation in 3T3-L1 adipocytes.
Am J Physiol Endocrinol Metab.
2008 Jul;295(1):E162-169.
Kaddai V, Le Marchand-Brustel
Y, Cormont M. Rab proteins in endocytosis and Glut4 trafficking.
Acta Physiol (Oxf). 2008 Jan;192(1):75-88. Review.
Ben Sahra I, Laurent
K, Loubat A, Giorgetti-Peraldi S, Colosetti P, Auberger P, Tanti
JF, Le Marchand-Brustel Y, Bost F.
The antidiabetic drug metformin
exerts an antitumoral effect in vitro and in vivo through a decrease
of cyclin D1 level.
Oncogene. 2008 Jun 5;27(25):3576-86.
2007
Aouadi M, Jager
J, Laurent K, Gonzalez
T, Cormont M, Binétruy B, Le Marchand-Brustel
Y, Tanti JF, Bost F.
p38MAP Kinase activity is required
for human primary adipocyte differentiation.
FEBS Lett. 2007 Dec 11;581(29):5591-6.
Epub 2007 Nov 13.
Jager
J, Grémeaux T, Cormont M , Le Marchand-Brustel Y, Tanti
JF. Interleukin-1b-induced insulin resistance in adipocytes
through down-regulation of IRS-1 expression. Endocrinology, 2007;
148: 241-251
Gauthier
NC, Monzo P, Gonzalez
T, Doye A, Oldani A, Gounon P, Ricci V, Cormont M, Boquet P. Early
endosomes associated with dynamic F-actin structures are required
for late trafficking of H. pylori VacA toxin. J Cell Biol. 2007;
177: 343-354.
2006
Aouadi
M, Laurent K, Prot M,
Le Marchand-Brustel Y, Binétruy B
and Bost F. Inhibition of p38MAPK increases adipogenesis
from embryonic to adult stages. Diabetes, 2006; 55: 281-289.
Mari
M, Monzo P, Kaddai V, Le Marchand-Brustel Y and Cormont M. The
Rab4 effector Rabip4 plays a role in intracellular trafficking
of Glut 4 in 3T3-L1 adipocytes. J Cell Sci, 2006;117: 1297-1306.
Vukmirica
J, Monzo P, Le Marchand-Brustel Y, Cormont M. The Rab4a
effector protein Rabip4 is involved in migration of NIH 3T3 fibroblasts.
J Biol Chem, 2006; 281: 36360-3 6368
Barrès
R, Grémeaux T, Gual P, Gonzalez T, Gugenheim j, Tran A,
Le Marchand-Brustel Y,
Tanti JF. Enigma interacts with
APS to control insulin-induced actin cytoskeleton remodeling and
glut4 translocation. Mol Endocrinol., 2006 Nov;20(11):2864-75.
Bost
F, Aouadi M, Caron L, Even P, Belmonte N, Prot M, Dani C, Hofman
P, Pages G, Pouyssegur J, Le Marchand-Brustel Y and Binetruy B.
The extracellular signal-regulated kinase isoform ERK1 is specifically
required for in vitro and in vivo adipogenesis. Diabetes, 2005;
54:402-411.
Monzo
P, Gauthier NC, Keslair F, Loubat A, Field CM, Le Marchand-Brustel
Y and Cormont M. Clues to CD2-associated protein involvement
in cytokinesis. Mol Biol Cell, 2005; 16:2891-2902.
Cormont
M, Meton I, Mari M, Monzo P, Keslair F, Gaskin C, McGraw TE and
Le Marchand-Brustel Y. CD2AP/CMS regulates endosome morphology
and traffic to the degradative pathway through its interaction
with Rab4 and c-Cbl.Traffic, 2003; 4:97-112.
Bouzakri
K, Roques M, Gual P, Espinosa S, Guebre-Egziabher F, Riou JP, Laville
M, Le Marchand-Brustel Y, Tanti JF and Vidal H. Reduced
activation of phosphatidylinositol-3 kinase and increased serine
636 phosphorylation of insulin receptor substrate-1 in primary
culture of skeletal muscle cells from patients with type 2 diabetes.
Diabetes, 2003; 52:1319-1325.
Gual
P, Grémeaux T, Gonzalez T, Le Marchand-Brustel Y and Tanti
JF. MAP kinases and mTOR mediate insulin-induced phosphorylation
of insulin receptor substrate-1 on serine residues 307, 612 and
632. Diabetologia, 2003; 46:1532-1542.
Gual
P, Gonzalez T, Grémeaux T, Barres R, Le Marchand-Brustel
Y and Tanti JF. Hyperosmotic stress inhibits insulin receptor
substrate-1 function by distinct mechanisms in 3T3-L1 adipocytes.
J Biol Chem, 2003; 278:26550-26557.
Bost
F, Caron L, Marchetti I, Dani C, Le Marchand-Brustel Y and Binetruy
B. Retinoic acid activation of the ERK pathway is required
for embryonic stem cell commitment into the adipocyte lineage.
Biochem J, 2002; 361:621-627.
Cormont
M, Mari M, Galmiche A, Hofman P and Le Marchand-Brustel Y.
A FYVE-finger-containing protein, Rabip4, is a Rab4 effector involved
in early endosomal traffic. Proc Natl Acad Sci USA, 2001; 98:1637-1642.
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